WYE

WYE

Investment Opportunities in Women's Health

Tro Kalayjian submits:The next several months will be an exciting time for the women’s health space, with several important events that may represent an opportunity for investors. Most notably, Pfizer (PFE) has completed data collection for it's 2186-patient study of Pristiq for the treatment of vasomotor symptoms, more commonly known as hot flashes. Wyeth, now part of Pfizer, began Pristiq's large trial in July of 2007, when the FDA asked Wyeth to produce a more comprehensive safety profile for Pristiq. At the time, Wyeth’s CEO, Robert Essner, said:Sales for Pristiq may top $2 billion, if Pristiq is approved for the "hot flash" indication.Complete Story »

Portfolio Tracking: John Paulson vs. Martin Whitman

Davy Bui submits: Scanning the 13F-HR SEC filing of Paulson and Co. suggests that John Paulson employs an active trading strategy. Readers can best view Paulson's moves in spreadsheet format but some broader themes do emerge:

  • Similar to some of the other money managers already profiled here (Berkowitz, Klarman), Paulson is bullish in the financial sector, as evidenced by sizable new positions in Wells Fargo (WFC), JP Morgan Chase (JPM) warrants, CIT Group (CIT) and Bank of America Units to complement his already huge holding of the bank's common stock (BAC). Paulson's fund also added substantively to existing stakes in Citigroup (C) and Suntrust Bank (STI).
  • While Paulson made some big moves in the financial sector, his single largest new add was Comcast (CMCSA), the cable and now media company.
  • Upon examining its holdings, it is evident the fund heavily employs a merger arbitrage strategy. The three large divestitures -- Schering Plough (SGP), Wyeth (WYE) and Liberty Media -- were all related to corporate merger/spin-off activity.
  • Perhaps the most intriguing insight to be gleaned from Paulson's holdings is that he appears to be a financial sector bull and a gold bug. The single largest holding revealed in the filing is the gold ETF (GLD) and the fund also has large stakes in several gold miners: AngloGold Ashanti (AU), Gold Fields (GFI) and Kinross Gold (KGC). Apparently, Paulson has taken the stance that the financial sector can thrive despite the massive economic uncertainty that a large gold holding would imply. Or, perhaps one is a hedge on the other.

Martin Whitman is receding more into the background these days and letting other managers helm the funds at Third Avenue. As such, Third Avenue's 13F-HR filing (available here in spreadsheet format) may not be a good reflection of Whitman's thinking. Whitman has always been a big proponent of moving into the financial sector at times of crisis but this time around, he was too early and picked some bad stocks to play. Despite numerous funds and managers, Third Avenue's filing was rather sedate:Complete Story »

Scorched-Earth Policy at Wyeth's Princeton Site?

Derek Lowe submits: This information comes to me secondhand, so I'm not sure how accurate it is. I hope it turns out not to be true. A correspondent writes to me that he's spoken this week to someone who had recently been at the former Wyeth (WYE) site in Princeton, which is in the process of shutting down. The usual practice is for industrial research sites to make surplus equipment available to academic labs and the like, but the report is that this isn't happening in this case. Instead, glassware is just being broken and tossed, along with a lot of other equipment, and the entire chemical reagent collection is supposedly going to be carted off by a waste disposal firm for incineration. That must be the commercially available stuff on the shelves - sometimes it's not worth the paperwork and trouble to send those on somewhere else, but sometimes it is. But the glassware and equipment definitely shouldn't be going to waste, but from the sound of this report, that's just what's happening.Complete Story »

The Decade that Was

Wade Slome submits:

We laughed, we cried, we kissed another ten years goodbye. It is virtually impossible to cram ten years into one article, nonetheless I will attempt to chronicle some of the central and silly events that bubble up in my memory bank. 2000Complete Story »

Galleon Group's 50 Largest Holdings

AlphaClone submits: The founders of the Galleon Group, a hedge fund started in 1997 and which has a technology and healthcare focus, have been charged with insider trading. Galleon is one of the 250 hedge and institutional investment funds that are available on AlphaClone. The fund's Top 10 Holding Clone, which invests quarterly in the the fund's ten largest holdings at the time they are disclosed, is up 48.2% so far this year but has not performed very well over time returning a negative 3.9% annualized over five years and a dismal negative 18% annualized since 2000 (all returns as of 10/15/09 close). We thought we'd list the fund's 50 largest holdings below (as of 6/30/09). Now that the fund will almost certainly wind down, perhaps there are some good short opportunities. Name Ticker 1 EBAY INC EBAY 2 GOOGLE INC GOOG 3 APPLE INC AAPL 4 OSI PHARMACEUTICALS... OSIP 5 BANK OF AMERICA COR... BAC 6 JP MORGAN CHASE & CO JPM 7 CISCO SYS INC CSCO 8 SPDR S&P 500 SPY 9 DELL INC DELL 10 NVIDIA CORP NVDA 11 E M C CORP MASS EMC 12 WYETH WYE 13 PEPSI BOTTLING GROU... PBG 14 MEMC ELECTR MATLS INC WFR 15 First Solar Inc FSLR 16 VERISIGN INC VRSN 17 YAHOO INC YHOO 18 ELECTRONIC ARTS INC ERTS 19 SPDR Gold GLD 20 INTEL CORP INTC 21 QUALCOMM INC QCOM 22 COGNIZANT TECHNOLOG... CTSH 23 FORD MTR CO DEL F 24 NATIONAL SEMICONDUC... NSM 25 NETEASE COM INC NTES 26 SUNTRUST BKS INC STI 27 TYCO INTERNATIONAL LTD TYC 28 TERADYNE INC TER 29 RESEARCH IN MOTION LTD RIMM 30 ALCON INC ACL 31 HEWLETT PACKARD CO HPQ 32 VISA INC V 33 AMAZON COM INC AMZN 34 BIOGEN IDEC INC BIIB 35 NOVELLUS SYS INC NVLS 36 ANADARKO PETE CORP APC 37 COMMSCOPE INC CTV 38 FTI CONSULTING INC FCN 39 PEPSICO INC PEP 40 ABERCROMBIE & FITCH CO ANF 41 F5 NETWORKS INC FFIV 42 LAM RESEARCH CORP LRCX 43 LEXMARK INTL NEW LXK 44 GAP INC DEL GPS 45 Seagate Tech STX 46 YINGLI GREEN ENERGY... YGE 47 RADIOSHACK CORP RSH 48 KLA-TENCOR CORP KLAC 49 FIDELITY NATIONAL F... FNF 50 ALLERGAN INC AGN Complete Story »

Ramius Capital Buys Drug Companies, Moves Out of ETFs

Todd Walker submits:Ramius Capital's most recent portfolio holdings reveal that the hedge fund manager has shifted its portfolio focus to drug manufacturers. The firm’s exposure to US Equity as of June 30th was $366mm, which is down from $788mm at the end of last year. Of the $136.41mm in added positions over the second quarter, $92.62mm was spent by Ramius Capital on healthcare giants Wyeth (WYE) and Schering Plough (SGP). At the same time, the hedge fund dumped its ETFs and opted for investing in individual equities, selling out of its entire $44.21mm of SPDR S&P 500 ETF (SPY) as well as $22.58mm of SPDR Energy Sector (XLE). Overall, the hedge fund sold $92.54 in ETFs over the quarter.Heeding the widespread call for future rebounds in commodity prices, the firm opened two new oil company positions and a coal company position. Also in line with the rest of the firm’s portfolio, two new information technology companies were added. The largest newly opened positions include:Complete Story »

The Few, The Proud, The Stocks Above Pre-Lehman Levels

Hickey and Walters (Bespoke) submit:
With nearly one year having passed since the bankruptcy of Lehman Brothers, we looked to see how many stocks have had a positive return since September 12th, 2008. Looking at the current members of the S&P 500 (500 stocks), 55 names in the index have registered gains since last September, and less than half of those (27) have seen double-digit returns. While only 27 stocks are up more than 10%, 374 are currently down more than 10%, and 33 of those are still down by more than 50%. Overall, the average stock in the S&P 500 is down 21.6% since 9/12/08.click to enlargeComplete Story »

Atticus Capital to Close $3 Billion Fund

Hickey and Walters (Bespoke) submit:
Atticus Capital announced earlier that it would shut its $3 billion flagship fund and liquidate its holdings citing personal reasons on the part of the company's founder. Below we summarize the firms's most recent holdings by sector (as of 6/30) along with its top three holdings in each sector based on its 13-F filing. As shown, the firm had a heavy concentration in the Financial sector, as it made up 29% of its long holdings. The largest of these was Bank of America (BAC) which made up 10.9% of its portfolio. This overweight in the Financial sector could be causing traders to sell ahead of the fund's upcoming liquidation and could be partly to blame for Financials being the worst performing sector today.Other positions making up more than 5% of the company's holdings on the long side were TRH, WYE, SGP, and PCZ.Complete Story »

Lines Blur Between Biotech and Pharma

Vincent Fernando submits: To me this shows us that biotech isn't just an offshoot of pharma anymore. It is pharma. It's the more sophisticated and effective way for drugs to be developed. Perhaps soon we won't even make the distinction between biotech and old "chemistry-based" pharma. They'll all just be pharma (though the distinction between small innovative companies and large pharma marketing platforms, Big Pharma, will continue to apply). This is because most future discoveries are likely to be biotech-based. This also shows, as the linked article says, that right now "Biotech is good at making drugs and Big Pharma is good at selling them". A recent Reuters article noted that “the world’s six biggest-selling drugs in 2014 will all be biotech products.” Interestingly enough, only one of them is actually owned, at least partially, by a biotech company. Top of the list, based on a report from research firm Evaluate Pharma, is Avastin (bevacizumab), an anti-cancer antibody with projected 2014 sales of $9.23 billion. To be fair, Avastin was developed by, and until recently marketed by, biotech bellwether Genentech. But Genentech was acquired by partner and part-owner Roche (RHHBY.PK) earlier this year. Pegged for second is Abbott’s (ABT) Humira (adalimumab), an anti-inflammatory antibody for rheumatoid arthritis, psoriasis, Crohn’s disease and other indications. The drug was originally developed through a collaboration between BASF and Cambridge Antibody Technology – but Abbott took over BASF’s part of the deal and CAT was acquired by AstraZeneca plc (AZN)..Complete Story »

Hoping Against Hope for Wyeth / Elan Alzheimer Dug

Derek Lowe submits: Here's an interesting look at the current state of the Alzheimer's field from Bloomberg. The current big hope is Wyeth (WYE) (and Elan (ELN))'s bapineuzumab, which I last wrote about here. That was after the companies reported what had to be considered less-than-hoped-for efficacy in the clinic. The current trial is the one sorted out by APOE4 status of the patients. After the earlier trial data, it seems unlikely that there's going to be a robust effect across the board - the people with the APOE4 mutation are probably the best hope for seeing real efficacy.Complete Story »

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